Deakin University
Browse

File(s) under permanent embargo

Survivin : a target from brain cancer to neurodegenerative disease

journal contribution
posted on 2010-12-01, 00:00 authored by Sara Baratchi, Rupinder Kanwar, Jagat Kanwar
Apoptosis is an important contributing factor during neuronal death in a variety of neurodegenerative disorders, including multiple sclerosis, Parkinson's disease and sciatic nerve injury. Whereas several clinical and preclinical studies have focused on the neuroprotective effects of caspase inhibitors, their clinical benefits are still unclear. Here, we discuss novel alternative strategies to protect neuronal cells from apoptotic death using members of the inhibitors of apoptosis (IAP) family. We specifically review the different roles of survivin, which is an important member of the IAP family that serves a dual role in the inhibition of apoptosis as well as a vital role in mitosis and cell division. Due to the various roles of survivin during cell division and apoptosis, targeting this protein illustrates a new therapeutic window for the treatment of neurodegenerative diseases.

History

Journal

Critical reviews in biochemistry and molecular biology

Volume

45

Issue

6

Pagination

535 - 554

Publisher

Informa Healthcare

Location

London, England

ISSN

1040-9238

eISSN

1549-7798

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2010, Informa Healthcare USA, Inc.