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Switching off the interactions between graphene oxide and doxorubicin using vitamin C: combining simplicity and efficiency in drug delivery

journal contribution
posted on 2018-02-28, 00:00 authored by Zhen Liu, J Liu, Tao Wang, Qiong Li, Paul FrancisPaul Francis, Colin BarrowColin Barrow, Wei DuanWei Duan, Wenrong YangWenrong Yang
Well-controlled, low-toxicity and highly efficient delivery systems for anticancer drugs are a key challenge for the development of a new class of nanocarrier systems for cancer chemotherapy. Graphene oxide (GO) has been developed to be a nanocarrier of anti-cancer drugs due to its large surface area and biocompatibility; however, understanding of the interface chemistry is very limited. In this work, we report efficient loading and controlled release of doxorubicin (DOX) using the tunable surface of GO. A deep understanding of the surface chemistry between GO and DOX is achieved using spectroscopies and atomic force microscopy. Hydrogen bonding and π-π stacking are confirmed to be the non-covalent interactions between the drugs and the carriers. As a result, improvement of DOX delivery from the GO surface can be achieved using vitamin C.

History

Journal

Journal of materials chemistry B

Volume

6

Issue

8

Pagination

1251 - 1259

Publisher

Royal Society of Chemistry

Location

Cambridge, Eng.

eISSN

2050-7518

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2018, The Royal Society of Chemistry