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Syngeneic-stem cell transplantation for HIV-related lymphoma

journal contribution
posted on 1999-06-24, 00:00 authored by P Campbell, H J Iland, J Gibson, D Joshua
The treatment of human immunodeficiency virus (HIV)-related lymphoma is beset by a number of therapeutic limitations. High-dose chemotherapy followed by peripheral blood stem cell transplantation (PBSCT) for relapsed disease is one option, but may be compromised by unacceptable treatment-related morbidity and mortality. We describe an HIV-positive male with relapsed immunoblastic non-Hodgkin's lymphoma (NHL) who successfully received salvage chemotherapy followed by a syngeneic PBSCT from his HIV negative (hepatitis C positive) brother. At 15 months post-transplant he remains in complete remission with low-level HIV viral load, an improved CD4 lymphocyte count and absent anti-hepatitis C antibodies. We believe selected patients with relapsed HIV-related NHL should be considered for high-dose therapy.

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Journal

British Journal of Haematology

Volume

105

Issue

3

Pagination

795 - 798

ISSN

0007-1048

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