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Synthesis and characterization of surface-enhanced Raman-scattered gold nanoparticles

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journal contribution
posted on 2013-11-01, 00:00 authored by Sushma Kalmodia, J Harjwani, R Rajeswari, Wenrong YangWenrong Yang, Colin BarrowColin Barrow, S Ramaprabhu, S Krishnakumar, S Elchuri
In this paper, we report a simple, rapid, and robust method to synthesize surface-enhanced Raman-scattered gold nanoparticles (GNPs) based on green chemistry. Vitis vinifera L. extract was used to synthesize noncytotoxic Raman-active GNPs. These GNPs were characterized by ultraviolet-visible spectroscopy, dynamic light-scattering, Fourier-transform infrared (FTIR), transmission electron microscopy (TEM), X-ray diffraction (XRD), and Raman spectroscopy. The characteristic surface plasmon-resonance band at ~528 nm is indicative of spherical particles, and this was confirmed by TEM. The N–H and C–O stretches in FTIR spectroscopy indicated the presence of protein molecules. The predominant XRD plane at (111) and (200) indicated the crystalline nature and purity of GNPs. GNPs were stable in the buffers used for biological studies, and exhibited no cytotoxicity in noncancerous MIO-M1 (Müller glial) and MDA-MB-453 (breast cancer) cell lines. The GNPs exhibited Raman spectral peaks at 570, 788, and 1,102 cm-1. These new GNPs have potential applications in cancer diagnosis, therapy, and ultrasensitive biomarker detection.

History

Journal

International journal of nanomedicine

Volume

8

Issue

1

Pagination

4327 - 4338

Publisher

Dove Medical Press

Location

Auckland, New Zealand

ISSN

1178-2013

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2013, Dove Medical Press