Synthesis of α-aminophosphonates using solvate ionic liquids
journal contributionposted on 2017-01-01, 00:00 authored by Daniel Eyckens, Luke HendersonLuke Henderson
A range of α-aminophosphonates were accessed in high yields and very rapidly, using solvate ionic liquids as the reaction media. Reactions typically required less than 10 minutes to go to completion and precipitation of these products into water excludes the use of traditional work up procedures, giving the products in very high crude purity. Excellent functional group tolerance for both the aldehyde and amine reaction partners was observed, and a range of bis-aminophosphonates derived from aromatic diamines were also accessed in high yield and purity.