keast-tas1r1andtas1r3-2018.pdf (233.79 kB)
TAS1R1 and TAS1R3 polymorphisms relate to energy and protein-rich food choices from a buffet meal respectively
journal contribution
posted on 2018-12-04, 00:00 authored by Pengfei Han, Russell KeastRussell Keast, Eugeni RouraEating behaviour in humans is a complex trait that involves sensory perception. Genetic variation in sensory systems is one of the factors influencing perception of foods. However, the extent that these genetic variations may determine food choices in a real meal scenario warrants further research. This study investigated how genetic variants of the umami taste receptor (TAS1R1/TAS1R3) related to consumption of umami-tasting foods. Thirty normal-weight adult subjects were offered "ad libitum" access to a variety of foods covering the full range of main taste-types for 40 min using a buffet meal arrangement. Buccal cell samples were collected and analysed for six single nucleotide polymorphisms (SNPs) reported previously related to the TAS1R1/TAS1R3 genes. Participants identified with the CC alleles of the TAS1R3 rs307355 and rs35744813 consumed significantly more protein from the buffet than T carriers. In addition, participants with GG genotype of the TAS1R1 SNP rs34160967 consumed more fat and calories as compared to the genotype group having the A alleles. In summary, these findings revealed a link between the SNPs variations of umami taster receptor gene and fat and protein intake from a buffet meal.
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Journal
NutrientsVolume
10Issue
12Article number
1906Pagination
1 - 10Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
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2072-6643Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, the authorsUsage metrics
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