panizzutti-telomerelengthand-2017.pdf (4.96 MB)
Telomere length and CCL11 levels are associated with gray matter volume and episodic memory performance in Schizophrenia: Evidence of pathological accelerated aging
journal contribution
posted on 2018-01-01, 00:00 authored by Leticia Sanguinetti Czepielewski, Raffael Massuda, Bruna Panizzutti ParryBruna Panizzutti Parry, Lucas Kich Grun, Florencia María Barbé-Tuana, Antonio Lucio Teixeira, Deanna M Barch, Clarissa S GamaSchizophrenia (SZ) is associated with increased somatic morbidity and mortality, in addition to cognitive impairments similar to those seen in normal aging, which may suggest that pathological accelerated aging occurs in SZ. Therefore, we aim to evaluate the relationships of age, telomere length (TL), and CCL11 (aging and inflammatory biomarkers, respectively), gray matter (GM) volume and episodic memory performance in individuals with SZ compared to healthy controls (HC). One hundred twelve participants (48 SZ and 64 HC) underwent clinical and memory assessments, structural MRI, and had their peripheral blood drawn for biomarkers analysis. Comparisons of group means and correlations were performed. Participants with SZ had decreased TL and GM volume, increased CCL11, and worse memory performance compared to HC. In SZ, shorter TL was related to increased CCL11, and both biomarkers were related to reduced GM volume, all of which were related to worse memory performance. Older age was only associated with reduced GM, but longer duration of illness was related with all the aforementioned variables. Younger age of disease onset was associated with increased CCL11 levels and worse memory performance. In HC, there were no significant correlations except between memory and GM. Our results are consistent with the hypothesis of accelerated aging in SZ. These results may indicate that it is not age itself, but the impact of the disease associated with a pathological accelerated aging that leads to impaired outcomes in SZ.
History
Journal
Schizophrenia BulletinVolume
44Issue
1Pagination
158 - 167Publisher
Oxford University PressLocation
Oxford, Eng.Publisher DOI
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ISSN
0586-7614eISSN
1745-1701Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2017, The AuthorsUsage metrics
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Science & TechnologyLife Sciences & BiomedicinePsychiatryschizophreniapathological accelerated agingbiomarkersepisodic memorygray matter volumeINCREASED SERUM-LEVELSPSYCHIATRIC-DISORDERSNEUROCOGNITIVE DEFICITSINFLAMMATORY CYTOKINESCOGNITIVE PERFORMANCEMENTAL-DISORDERSBIPOLAR DISORDERBRAINMETAANALYSISHYPOTHESIS
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