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The ADAMTS hyalectanase family: Biological insights from diverse species
journal contribution
posted on 2016-01-01, 00:00 authored by Carolyn Dancevic, Daniel Mcculloch, Alister WardAlister WardThe a disintegrin-like and metalloproteinase with thrombospondin type-1 motifs (ADAMTS) family of metzincins are complex secreted proteins that have diverse functions during development. The hyalectanases (ADAMTS1, 4, 5, 8, 9, 15 and 20) are a subset of this family that have enzymatic activity against hyalectan proteoglycans, the processing of which has important implications during development. This review explores the evolution, expression and developmental functions of the ADAMTS family, focusing on the ADAMTS hyalectanases and their substrates in diverse species. This review gives an overview of how the family and their substrates evolved from non-vertebrates to mammals, the expression of the hyalectanases and substrates in different species and their functions during development, and how these functions are conserved across species.
History
Journal
Biochemical JournalVolume
473Issue
14Pagination
2011 - 2022Publisher
PORTLAND PRESS LTDLocation
EnglandPublisher DOI
ISSN
0264-6021eISSN
1470-8728Language
EnglishPublication classification
C Journal article; C1 Refereed article in a scholarly journalCopyright notice
2016, The AuthorsUsage metrics
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Categories
Keywords
Science & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular Biologya disintegrin-like and metalloproteinase with thrombospondin type-1 motifs (ADAMTS)embryogenesisevolutionexpressionhyalectanasehyalectan substratesCHONDROITIN SULFATE PROTEOGLYCANHYALURONAN-BINDING PROTEOGLYCANSINTERDIGITAL WEB REGRESSIONIN-SITU HYBRIDIZATIONEXTRACELLULAR-MATRIXCAENORHABDITIS-ELEGANSTHROMBOSPONDIN MOTIFSCELL-MIGRATIONARTICULAR-CARTILAGEMOLECULAR-CLONING