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The APOE ϵ4 Allele Is Associated with Lower Selenium Levels in the Brain: Implications for Alzheimer's Disease

Version 2 2024-06-13, 11:03
Version 1 2017-10-17, 10:53
journal contribution
posted on 2024-06-13, 11:03 authored by B Rita Cardoso, DJ Hare, M Lind, CA McLean, I Volitakis, SM Laws, CL Masters, AI Bush, BR Roberts
The antioxidant activity of selenium, which is mainly conferred by its incorporation into dedicated selenoproteins, has been suggested as a possible neuroprotective approach for mitigating neuronal loss in Alzheimer's disease. However, there is inconsistent information with respect to selenium levels in the Alzheimer's disease brain. We examined the concentration and cellular compartmentalization of selenium in the temporal cortex of Alzheimer's disease and control brain tissue. We found that Alzheimer's disease was associated with decreased selenium concentration in both soluble (i.e., cytosolic) and insoluble (i.e., plaques and tangles) fractions of brain homogenates. The presence of the APOE ε4 allele correlated with lower total selenium levels in the temporal cortex and a higher concentration of soluble selenium. Additionally, we found that age significantly contributed to lower selenium concentrations in the peripheral membrane-bound and vesicular fractions. Our findings suggest a relevant interaction between APOE ε4 and selenium delivery into brain, and show changes in cellular selenium distribution in the Alzheimer's disease brain.

History

Journal

ACS chemical neuorscience

Volume

8

Pagination

1459-1464

Location

Washington, D.C.

eISSN

1948-7193

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2017, American Chemical Society

Issue

7

Publisher

American Chemical Society