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The CD39-adenosinergic axis in the pathogenesis of renal ischemia-reperfusion injury
journal contribution
posted on 2013-06-01, 00:00 authored by Veena Roberts, Bo Lu, Siddharth Rajakumar, Peter J Cowan, Karen DwyerKaren DwyerHypoxic injury occurs when the blood supply to an organ is interrupted; subsequent reperfusion halts ongoing ischemic damage but paradoxically leads to further inflammation. Together this is termed ischemia-reperfusion injury (IRI). IRI is inherent to organ transplantation and impacts both the short- and long-term outcomes of the transplanted organ. Activation of the purinergic signalling pathway is intrinsic to the pathogenesis of, and endogenous response to IRI. Therapies targeting the purinergic pathway in IRI are an attractive avenue for the improvement of transplant outcomes and the basis of ongoing research. This review aims to examine the role of adenosine receptor signalling and the ecto-nucleotidases, CD39 and CD73, in IRI, with a particular focus on renal IRI.
History
Journal
Purinergic signallingVolume
9Issue
2Pagination
135 - 143Publisher
SpringerLocation
Berlin, GermanyPublisher DOI
eISSN
1573-9546Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2012, SpringerUsage metrics
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No categories selectedKeywords
AdenosineAnimalsAntigens, CDApyraseHumansKidneyKidney TransplantationReperfusion InjurySignal TransductionScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyNeurosciencesNeurosciences & NeurologyIschemia-reperfusion injuryRenal transplantPurinergic signallingAdenosine receptorEctonucleotidaseREGULATORY T-CELLSRECEPTOR KNOCKOUT MICEHIF-DEPENDENT INDUCTIONOF-WISCONSIN SOLUTIONACUTE KIDNEY INJURYECTO-5'-NUCLEOTIDASE CD73MYOCARDIAL PROTECTION5'-ADENOSINE MONOPHOSPHATEADENOSINE GENERATIONVASCULAR LEAKAGE
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