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The Concept of 'Metabolic Jet Lag' in the Pathophysiology of Bipolar Disorder: Implications for Research and Clinical Care
journal contribution
posted on 2023-03-06, 05:20 authored by E Koning, A McDonald, A Bambokian, FA Gomes, J Vorstman, Michael BerkMichael Berk, J Fabe, RS McIntyre, R Milev, RB Mansur, E BrietzkeBipolar Disorder (BD) is a potentially chronic mental disorder marked by recurrent depressive and manic episodes, circadian rhythm disruption, and changes in energetic metabolism. 'Metabolic jet lag' refers to a state of shift in circadian patterns of energy homeostasis, affecting neuroendocrine, immune and adipose tissue function, expressed through behavioral changes such as irregularities in sleep and appetite. Risk factors include genetic variation, mitochondrial dysfunction, lifestyle factors, poor gut microbiome health and abnormalities in hunger, satiety, and hedonistic function. Evidence suggests metabolic jet lag is a core component of BD pathophysiology, as individuals with BD frequently exhibit irregular eating rhythms and circadian desynchronization of their energetic metabolism, which is associated with unfavourable clinical outcomes. Although current diagnostic criteria lack any assessment of eating rhythms, technological advancements including mobile phone applications and ecological momentary assessment allow for the reliable tracking of biological rhythms. Overall, methodological refinement of metabolic jet lag assessment will increase knowledge in this field and stimulate the development of interventions targeting metabolic rhythms, such as time-restricted eating.
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Journal
CNS SpectrumsPagination
1-10Location
United StatesPublisher DOI
ISSN
1092-8529eISSN
2165-6509Language
enPublisher
Cambridge University Press (CUP)Usage metrics
Keywords
Bipolar disordercircadian rhythmdepressionenergetic metabolismmaniamental healthmetabolic jet lagneurosciencenutritionpsychiatrySerious Mental IllnessClinical ResearchNutritionMental HealthBehavioral and Social ScienceDepressionBrain DisordersNeurosciencesBipolar DisorderSleep ResearchObesityPrevention3 Good Health and Well BeingClinical Sciences not elsewhere classifiedNeurosciences not elsewhere classified
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