richardson-drosophilamelanogaster-2012.pdf (857.3 kB)
The Drosophila melanogaster Genetic Reference Panel
journal contribution
posted on 2012-02-09, 00:00 authored by T F C Mackay, S Richards, E A Stone, A Barbadilla, J F Ayroles, D Zhu, S Casillas, Y Han, M M Magwire, J M Cridland, Mark RichardsonMark Richardson, R R H Anholt, M Barrón, C Bess, K P Blankenburg, M A Carbone, D Castellano, L Chaboub, L Duncan, Z Harris, M Javaid, J C Jayaseelan, S N Jhangiani, K W Jordan, F Lara, F Lawrence, S L Lee, P Librado, R S Linheiro, R F Lyman, A J Mackey, M Munidasa, D M Muzny, L Nazareth, I Newsham, L Perales, L-L Pu, C Qu, M Ràmia, J G Reid, S M Rollmann, J Rozas, N Saada, L Turlapati, K C Worley, Y-Q Wu, A Yamamoto, Y Zhu, C M Bergman, K R Thornton, D Mittelman, R A GibbsA major challenge of biology is understanding the relationship between molecular genetic variation and variation in quantitative traits, including fitness. This relationship determines our ability to predict phenotypes from genotypes and to understand how evolutionary forces shape variation within and between species. Previous efforts to dissect the genotype-phenotype map were based on incomplete genotypic information. Here, we describe the Drosophila melanogaster Genetic Reference Panel (DGRP), a community resource for analysis of population genomics and quantitative traits. The DGRP consists of fully sequenced inbred lines derived from a natural population. Population genomic analyses reveal reduced polymorphism in centromeric autosomal regions and the X chromosome, evidence for positive and negative selection, and rapid evolution of the X chromosome. Many variants in novel genes, most at low frequency, are associated with quantitative traits and explain a large fraction of the phenotypic variance. The DGRP facilitates genotype-phenotype mapping using the power of Drosophila genetics.
History
Journal
NatureVolume
482Issue
7384Pagination
173 - 178Publisher
Nature Publishing GroupLocation
London, Eng.Publisher DOI
eISSN
1476-4687Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2012, Macmillan Publishers LimitedUsage metrics
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No categories selectedKeywords
AllelesAnimalsCentromereChromosomes, InsectDrosophila melanogasterGenome-Wide Association StudyGenomicsGenotypePhenotypePolymorphism, Single NucleotideQuantitative Trait LociSelection, GeneticStarvationTelomereX ChromosomeScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsMCDONALD-KREITMAN TESTSLIGHTLY DELETERIOUS MUTATIONSADAPTIVE PROTEIN EVOLUTIONQUANTITATIVE TRAITSMOLECULAR EVOLUTIONDNA POLYMORPHISMPOPULATION-SIZERECOMBINATIONSELECTIONCHALLENGES
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