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The Global Epidemiological Transition in Cardiovascular Diseases: Unrecognised Impact of Endemic Infections on Peripheral Artery Disease

Version 3 2024-06-20, 00:10
Version 2 2024-06-03, 03:25
Version 1 2024-03-08, 04:24
journal contribution
posted on 2024-06-20, 00:10 authored by Paul AgiusPaul Agius, JC Cutts, P Song, I Rudan, D Rudan, V Aboyans, MM McDermott, MH Criqui, FGR Fowkes, FJI Fowkes
AbstractAn epidemiological transition in the prevalence of peripheral artery disease (PAD) is taking place especially in low- and middle-income countries (LMICs) where an ageing population and adoption of western lifestyles are associated with an increase in PAD. We discuss the limited evidence which suggests that infection, potentially mediated by inflammation, may be a risk factor for PAD, and show by means of an ecological analysis that country-level prevalence of the major endemic infections of HIV, tuberculosis and malaria are associated with the prevalence of PAD. While further research is required, we propose that scientists and health authorities pay more attention to the interplay between communicable and non-communicable diseases, and we suggest that limiting the occurrence of endemic infections might have some effect on slowing the epidemiological transition in PAD.

History

Journal

Journal of Epidemiology and Global Health

Volume

12

Pagination

219-223

Location

Amsterdam, The Netherlands

ISSN

2210-6006

eISSN

2210-6014

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

3

Publisher

Elsevier