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The Impact of Combined Nutrition and Exercise Interventions in Patients with Chronic Kidney Disease

journal contribution
posted on 2024-03-07, 22:59 authored by M de Geus, M Dam, WJ Visser, KJR Ipema, AME de Mik-van Egmond, M Tieland, PJM Weijs, HM Kruizenga
Combined nutrition and exercise interventions potentially improve protein-energy wasting/malnutrition-related outcomes in patients with chronic kidney disease (CKD). The aim was to systematically review the effect of combined interventions on nutritional status, muscle strength, physical performance and QoL. MEDLINE, Cochrane, Embase, Web of Science and Google Scholar were searched for studies up to the date of July 2023. Methodological quality was appraised with the Cochrane risk-of-bias tool. Ten randomized controlled trials (nine publications) were included (334 patients). No differences were observed in body mass index, lean body mass or leg strength. An improvement was found in the six-minute walk test (6-MWT) (n = 3, MD 27.2, 95%CI [7 to 48], p = 0.008), but not in the timed up-and-go test. No effect was found on QoL. A positive impact on 6-MWT was observed, but no improvements were detected in nutritional status, muscle strength or QoL. Concerns about reliability and generalizability arise due to limited statistical power and study heterogeneity of the studies included.

History

Journal

Nutrients

Volume

16

Article number

406

Pagination

406-406

Location

Switzerland

ISSN

2072-6643

eISSN

2072-6643

Language

en

Issue

3

Publisher

MDPI AG