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The Omp85 family of proteins is essential for outer membrane biogenesis in mitochondria and bacteria
journal contribution
posted on 2004-01-01, 00:00 authored by I Gentle, K Gabriel, Peter BeechPeter Beech, R Waller, T LithgowIntegral proteins in the outer membrane of mitochondria control all aspects of organelle biogenesis, being required for protein import, mitochondrial fission, and, in metazoans, mitochondrial aspects of programmed cell death. How these integral proteins are assembled in the outer membrane had been unclear. In bacteria, Omp85 is an essential component of the protein insertion machinery, and we show that members of the Omp85 protein family are also found in eukaryotes ranging from plants to humans. In eukaryotes, Omp85 is present in the mitochondrial outer membrane. The gene encoding Omp85 is essential for cell viability in yeast, and conditional omp85 mutants have defects that arise from compromised insertion of integral proteins like voltage-dependent anion channel (VDAC) and components of the translocase in the outer membrane of mitochondria (TOM) complex into the mitochondrial outer membrane.
History
Journal
Journal of cell biologyVolume
164Issue
1Pagination
19 - 24Publisher
Rockefeller University PressLocation
New York, N.Y.Publisher DOI
ISSN
0021-9525Language
engNotes
Published online 29 December 2003Publication classification
C1 Refereed article in a scholarly journalCopyright notice
2004, The Rockefeller University PressUsage metrics
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