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The STARS signaling pathway: a key regulator of skeletal muscle function

journal contribution
posted on 01.09.2014, 00:00 authored by Severine LamonSeverine Lamon, Marita Wallace, Aaron RussellAaron Russell
During the last decade, the striated muscle activator of Rho signaling (STARS), a muscle-specific protein, has been proposed to play an increasingly important role in skeletal muscle growth, metabolism, regeneration and stress adaptation. STARS influences actin dynamics and, as a consequence, regulates the myocardin-related transcription factor A/serum response factor (MRTF-A/SRF) transcriptional program, a well-known pathway controlling skeletal muscle development and function. Muscle-specific stress conditions, such as exercise, positively regulates, while disuse and degenerative muscle diseases are associated with a downregulation of STARS and its downstream partners, suggesting a pivotal role for STARS in skeletal muscle health. This review provides a comprehensive overview of the known role and regulation of STARS and the members of its signaling pathway, RhoA, MRTF-A and SRF, in skeletal muscle.

History

Journal

Pflügers archiv - European journal of physiology

Volume

466

Issue

9

Pagination

1659 - 1671

Publisher

Springer

Location

Heidelberg, Germany

eISSN

1432-2013

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2014, Springer