File(s) under permanent embargo

The amyloid-β peptide and its role in Alzheimer's disease

journal contribution
posted on 2001-05-01, 00:00 authored by A B Clippingdale, J D Wade, Colin BarrowColin Barrow
Amyloid formation plays a central role in the cause and progression of Alzheimer's disease. The major component of this amyloid is the amyloid-beta (A beta) peptide, which is currently the subject of intense study. This review discusses some recent studies in the area of A beta synthesis, purification and structural analysis. Also discussed are proposed mechanisms for A beta-induced neurotoxicity and some recent advances in the development of A beta-related therapeutic strategies.

History

Journal

Journal of peptide science

Volume

7

Issue

5

Pagination

227 - 249

Publisher

Wiley-Blackwell

Location

Chichester, Eng.

ISSN

1075-2617

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2001, European Peptide Society and John Wiley & Sons