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The anti-inflammatory and pharmacological actions of oleocanthal, a phenolic contained in extra virgin olive oil

Version 2 2024-06-03, 09:10
Version 1 2015-08-20, 13:46
journal contribution
posted on 2024-06-03, 09:10 authored by L Lucas, S Cicerale, Russell KeastRussell Keast
Extra virgin olive oil (EVOO) is consumed as part of the health promoting Mediterranean diet and contains several phenolic compounds that are responsible for the unique and distinctive flavour of EVOO. The phenolic fraction of EVOO also imparts many beneficial effects on human health. Oleocanthal is an EVOO phenolic that shares a unique perceptual quality with the non-steroidal anti-inflammatory drug (NSAID) ibuprofen and also mimics the anti-inflammatory actions of this drug. Oleocanthal has therefore been deemed a naturally occurring NSAID because of its demonstrated attenuation of cyclooxygenase (COX) activity in a dose dependent manner. New and emerging research has reported that oleocanthal also acts on inflammatory markers associated with neurodegenerative disease, joint degenerative disease, and cancer. This review will give an up-to-date summary of the history of oleocanthal and the current evidence establishing oleocanthal as a potent natural anti-inflammatory agent.

History

Journal

Anti-inflammatory and anti-allergy agents in medicinal chemistry

Volume

10

Pagination

399-406

Location

Mersin, Turkey

ISSN

1871-5230

eISSN

1875-614X

Language

eng

Publication classification

C Journal article, C1.1 Refereed article in a scholarly journal

Copyright notice

2011, Bentham Science Publishers

Issue

6

Publisher

Bentham Science Publishers