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The association between major depressive disorder, use of antidepressants and bone mineral density (BMD) in men.

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journal contribution
posted on 2015-06-01, 00:00 authored by P H Rauma, Julie PascoJulie Pasco, Michael BerkMichael Berk, Amanda StuartAmanda Stuart, H Koivumaa-Honkanen, R J Honkanen, Jason HodgeJason Hodge, Lana WilliamsLana Williams
OBJECTIVE: Both depression and use of antidepressants have been negatively associated with bone mineral density (BMD) but mainly in studies among postmenopausal women. Therefore, the aim of this study was to investigate these relationships in men. METHODS: Between 2006 and 2011, 928 men (aged 24-98 years) from the Geelong Osteoporosis Study completed a comprehensive questionnaire, clinical measurements and had BMD assessments at the forearm, spine, total hip and total body. Major depressive disorder (MDD) was identified using a structured clinical interview (SCID-I/NP). The cross-sectional associations between BMD and both MDD and antidepressant use were analyzed using multivariable linear regression. RESULTS: Of the study population, 84 (9.1%) men had a single MDD episode, 50 (5.4%) had recurrent episodes and 65 (7.0%) were using antidepressants at the time of assessment. Following adjustments, recurrent MDD was associated with lower BMD at the forearm and total body (-6.5%, P=0.033 and -2.5%, P=0.033, respectively compared to men with no history of MDD), while single MDD episodes were associated with higher BMD at the total hip (+3.4%, P=0.030). Antidepressant use was associated with lower BMD only in lower-weight men (<75-110 kg depending on bone site). CONCLUSIONS: Both depression and use of antidepressants should be taken into account as possible risk factors for osteoporosis in men.

History

Journal

Journal of Musculoskeletal and Neuronal Interactions

Volume

15

Issue

2

Pagination

177 - 185

Publisher

International Society of Musculoskeletal and Neuronal Interactions

Location

Greece

ISSN

1108-7161

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2015, International Society of Musculoskeletal and Neuronal Interactions