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The association between migrant status and transition in an ultra-high risk for psychosis population

Version 2 2024-06-05, 11:39
Version 1 2021-07-22, 08:19
journal contribution
posted on 2024-06-05, 11:39 authored by B O’Donoghue, H Geros, H Sizer, J Addington, GP Amminger, CE Beaden, KS Cadenhead, TD Cannon, BA Cornblatt, GE Berger, EYH Chen, L de Haan, JA Hartmann, IB Hickie, HK Ising, S Lavoie, A Lin, C Markulev, DH Mathalon, TH McGlashan, NG Mifsud, N Mossaheb, DH Nieman, M Nordentoft, DO Perkins, A Riecher-Rössler, MR Schäfer, M Schlögelhofer, LJ Seidman, S Smesny, A Thompson, MT Tsuang, M van der Gaag, S Verma, EF Walker, SJ Wood, SW Woods, HP Yuen, Alison YungAlison Yung, PD McGorry, B Nelson
Purpose: Migrant status is one of the most replicated and robust risk factors for developing a psychotic disorder. This study aimed to determine whether migrant status in people identified as Ultra-High Risk for Psychosis (UHR) was associated with risk of transitioning to a full-threshold psychotic disorder. Methods: Hazard ratios for the risk of transition were calculated from five large UHR cohorts (n = 2166) and were used to conduct a meta-analysis using the generic inverse-variance method using a random-effects model. Results: 2166 UHR young people, with a mean age of 19.1 years (SD ± 4.5) were included, of whom 221 (10.7%) were first-generation migrants. A total of 357 young people transitioned to psychosis over a median follow-up time of 417 days (I.Q.R.147–756 days), representing 17.0% of the cohort. The risk of transition to a full-threshold disorder was not increased for first-generation migrants, (HR = 1.08, 95% CI 0.62–1.89); however, there was a high level of heterogeneity between studies The hazard ratio for second-generation migrants to transition to a full-threshold psychotic disorder compared to the remainder of the native-born population was 1.03 (95% CI 0.70–1.51). Conclusions: This meta-analysis did not find a statistically significant association between migrant status and an increased risk for transition to a full-threshold psychotic disorder; however, several methodological issues could explain this finding. Further research should focus on examining the risk of specific migrant groups and also ensuring that migrant populations are adequately represented within UHR clinics.

History

Journal

Social Psychiatry and Psychiatric Epidemiology

Volume

56

Pagination

943-952

Location

Berlin, Germany

ISSN

0933-7954

eISSN

1433-9285

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Issue

6

Publisher

Springer

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