The cytotoxic, inflammatory and oxidative potential of coconut oil-substituted diesel emissions on bronchial epithelial cells at an air-liquid interface
Version 2 2024-06-05, 02:40Version 2 2024-06-05, 02:40
Version 1 2019-08-09, 08:17Version 1 2019-08-09, 08:17
journal contribution
posted on 2019-07-01, 00:00 authored by A Vaughan, Svetlana StevanovicSvetlana Stevanovic, A P W Banks, Ali ZareAli Zare, M M Rahman, R V Bowman, K M Fong, Z D Ristovski, I A Yang© 2019, Springer-Verlag GmbH Germany, part of Springer Nature. Diesel emissions contain high levels of particulate matter (PM) which can have a severe effect on the airways. Diesel PM can be effectively reduced with the substitution of diesel fuel with a biofuel such as vegetable oil. Unfortunately, very little is known about the cellular effects of these alternative diesel emissions on the airways. The aim of this study was to test whether coconut oil substitution in diesel fuel reduces the adverse effect of diesel emission exposure on human bronchial epithelial cells. Human bronchial epithelial cells were cultured at air-liquid interface for 7 days and exposed to diesel engine emissions from conventional diesel fuel or diesel fuel blended with raw coconut oil at low (10%), moderate (15%) and high (20%) proportions. Cell viability, inflammation, antioxidant production and xenobiotic metabolism were measured. Compared to conventional diesel, low fractional coconut oil substitution (10% and 15%) reduced inflammation and increased antioxidant expression, whereas higher fractional coconut oil (20%) reduced cell viability and increased inflammation. Therefore, cellular responses after exposure to alternative diesel emission are dependent on fuel composition.
History
Journal
Environmental science and pollution researchPublisher
SpingerLocation
Cham, SwitzerlandPublisher DOI
ISSN
0944-1344eISSN
1614-7499Language
engNotes
In PressPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2019, Springer-Verlag GmbH Germany, part of Springer NatureUsage metrics
Keywords
Science & TechnologyLife Sciences & BiomedicineEnvironmental SciencesEnvironmental Sciences & EcologyDieselBronchial epithelial cellsAir pollutionCoconut oilInflammationAntioxidantsToxicityOBSTRUCTIVE PULMONARY-DISEASEEXHAUST PARTICLESPARTICULATE MATTERDNA-DAMAGELUNG-CELLSBIODIESELSTRESSIMPACTCOMBUSTIONGENERATIONMechanical Engineering
Licence
Exports
RefWorksRefWorks
BibTeXBibTeX
Ref. managerRef. manager
EndnoteEndnote
DataCiteDataCite
NLMNLM
DCDC