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The effect of DOCA and 9 alpha-fludrocortisone on renal renin content and production

journal contribution
posted on 1987-03-01, 00:00 authored by J Menting, T Morgan, G Barrett, Robert Di Nicolantonio
1. DOCA and 9 alpha-fludrocortisone were given to rats. 2. Plasma renin fell rapidly with both treatments. 3. Renal renin fell slowly to a low level. 4. Renal renin fell to a lower level with DOCA than with 9 alpha-fludrocortisone. 5. When DOCA and 9 alpha-fludrocortisone were stopped plasma renin levels rose rapidly and the renal renin levels increased. 6. The data suggest that synthesis is altered rapidly but it takes a prolonged time for the kidney to become depleted of renin due to the high tissue stores and the associated inhibition of release.

History

Journal

Clinical and Experimental Pharmacology and Physiology

Volume

14

Issue

3

Pagination

259 - 262

Publisher

Wiley-Blackwell Publishing Asia

Location

Richmond, Vic.

ISSN

0305-1870

Language

eng

Publication classification

CN.1 Other journal article

Copyright notice

1987, Wiley-Blackwell Publishing Asia