marx-effectofpolyphenol-2017.pdf (675.83 kB)
The effect of Polyphenol-rich interventions on cardiovascular risk factors in haemodialysis: a systematic review and meta-analysis
journal contribution
posted on 2017-12-11, 00:00 authored by Wolf MarxWolf Marx, J Kelly, S Marshall, S Nakos, K Campbell, C ItsiopoulosEnd-stage kidney disease is a strong risk factor for cardiovascular-specific mortality. Polyphenol-rich interventions may attenuate cardiovascular disease risk factors; however, this has not been systematically evaluated in the hemodialysis population. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines, the following databases were searched: Cochrane Library (http://www.cochranelibrary.com/), MEDLINE (https://health.ebsco.com/products/medline-with-full-text), Embase (https://www.elsevier.com/solutions/embase-biomedical-research), and CINAHL (https://www.ebscohost.com/nursing/products/cinahl-databases/cinahl-complete). Meta-analyses were conducted for measures of lipid profile, inflammation, oxidative stress, and blood pressure. Risk of bias was assessed using the Cochrane Collaboration Risk of Bias tool and quality of the body of evidence was assessed by the Grading of Recommendations, Assessment, Development and Evaluation (GRADE) methodology. Twelve studies were included for review. Polyphenol-rich interventions included soy, cocoa, pomegranate, grape, and turmeric. Polyphenol-rich interventions significantly improved diastolic blood pressure (Mean Difference (MD) -5.62 mmHg (95% Confidence Interval (CI) -8.47, -2.78); I² = 2%; p = 0.0001), triglyceride levels (MD -26.52 mg/dL (95% CI -47.22, -5.83); I² = 57%; p = 0.01), and myeloperoxidase (MD -90.10 (95% CI -135.84, -44.36); I² = 0%; p = 0.0001). Included studies generally had low or unclear risks of bias. The results of this review provide preliminary support for the use of polyphenol-rich interventions for improving cardiovascular risk markers in haemodialysis patients. Due to the limited number of studies for individual polyphenol interventions, further studies are required to provide recommendations regarding individual polyphenol intervention and dose.
History
Journal
NutrientsVolume
9Issue
12Article number
1345Publisher
M D P I AGLocation
Basel, SwitzerlandPublisher DOI
Link to full text
eISSN
2072-6643Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2017, The AuthorsUsage metrics
Categories
No categories selectedKeywords
blood pressurecardiovascularcocoadialysisinflammationmeta-analysisoxidative stresspolyphenolpomegranatereviewsoyturmericScience & TechnologyLife Sciences & BiomedicineNutrition & DieteticsCHRONIC KIDNEY-DISEASEEXTRACT SUPPLEMENTATIONDOUBLE-BLINDSOY PROTEINMORTALITYBIOAVAILABILITYRESVERATROLFLAVONOIDS
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC