lamon-theeffectofacutesleep-2021.pdf (1.19 MB)
Download file

The effect of acute sleep deprivation on skeletal muscle protein synthesis and the hormonal environment

Download (1.19 MB)
journal contribution
posted on 05.01.2021, 00:00 authored by Severine LamonSeverine Lamon, A Morabito, E Arentson-Lantz, O Knowles, G E Vincent, Dominique CondoDominique Condo, Sarah AlexanderSarah Alexander, Andrew GarnhamAndrew Garnham, D Paddon-Jones, Brad AisbettBrad Aisbett
Chronic sleep loss is a potent catabolic stressor, increasing the risk of metabolic dysfunction and loss of muscle mass and function. To provide mechanistic insight into these clinical outcomes, we sought to determine if acute sleep deprivation blunts skeletal muscle protein synthesis and promotes a catabolic environment. Healthy young adults (N = 13; seven male, six female) were subjected to one night of total sleep deprivation (DEP) and normal sleep (CON) in a randomized cross‐over design. Anabolic and catabolic hormonal profiles were assessed across the following day. Postprandial muscle protein fractional synthesis rate (FSR) was assessed between 13:00 and 15:00 and gene markers of muscle protein degradation were assessed at 13:00. Acute sleep deprivation reduced muscle protein synthesis by 18% (CON: 0.072 ± 0.015% vs. DEP: 0.059 ± 0.014%·h‐1, p = .040). In addition, sleep deprivation increased plasma cortisol by 21% (p = .030) and decreased plasma testosterone by 24% (p = .029). No difference was found in the markers of protein degradation. A single night of total sleep deprivation is sufficient to induce anabolic resistance and a procatabolic environment. These acute changes may represent mechanistic precursors driving the metabolic dysfunction and body composition changes associated with chronic sleep deprivation.

History

Journal

Physiological Reports

Volume

9

Issue

1

Article number

e14660

Pagination

1 - 13

Publisher

Wiley

Location

Hoboken, NJ

ISSN

2051-817X

eISSN

2051-817X

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2021, The Authors