dunstan-effectofbreaking-2020.pdf (1.02 MB)
The effect of breaking up prolonged sitting on paired associative stimulation-induced plasticity
journal contribution
posted on 2020-01-01, 00:00 authored by E Bojsen-Møller, M M Ekblom, O Tarassova, David DunstanDavid Dunstan, O EkblomPaired associative stimulation (PAS) can induce plasticity in the motor cortex, as measured by changes in corticospinal excitability (CSE). This effect is attenuated in older and less active individuals. Although a single bout of exercise enhances PAS-induced plasticity in young, physically inactive adults, it is not yet known if physical activity interventions affect PAS-induced neuroplasticity in middle-aged inactive individuals. Sixteen inactive middle-aged office workers participated in a randomized cross-over design investigating how CSE and short-interval intracortical inhibition (SICI) were affected by PAS preceded by 3 h of sitting (SIT), 3 h of sitting interrupted every 30 min by 3 min of frequent short bouts of physical activity (FPA) and 2.5 h of sitting followed by 25 min of moderate-intensity exercise (EXE). Transcranial magnetic stimulation was applied over the primary motor cortex (M1) of the dominant abductor pollicis brevis to induce recruitment curves before and 5 min and 30 min post-PAS. Linear mixed models were used to compare changes in CSE using time and condition as fixed effects and subjects as random effects. There was a main effect of time on CSE and planned within-condition comparisons showed that CSE was significantly increased from baseline to 5 min and 30 min post-PAS, in the FPA condition, with no significant changes in the SIT or EXE conditions. SICI decreased from baseline to 5 min post-PAS, but this was not related to changes in CSE. Our findings suggest that in middle-aged inactive adults, FPAs may promote corticospinal neuroplasticity. Possible mechanisms are discussed.
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Journal
Experimental Brain ResearchVolume
238Pagination
2497 - 2506Publisher
SpringerLocation
Heidelberg, GermanyPublisher DOI
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ISSN
0014-4819eISSN
1432-1106Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
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