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The effect of depressive symptoms on disability-free survival in healthy older adults: A prospective cohort study
journal contribution
posted on 2023-02-10, 01:51 authored by G Roebuck, Mojtaba Lotfaliany Abrand AbadiMojtaba Lotfaliany Abrand Abadi, B Agustini, M Forbes, Mohammadreza MohebbiMohammadreza Mohebbi, J McNeil, RL Woods, CM Reid, MR Nelson, RC Shah, J Ryan, AB Newman, A Owen, R Freak-Poli, N Stocks, M BerkBackground: Gerontology and ageing research are increasingly focussing on healthy life span (healthspan), the period of life lived free of serious disease and disability. Late-life depression (LLD) is believed to impact adversely on physical health. However, no studies have examined its effect on healthspan. This study investigated the effect of LLD and subthreshold depression on disability-free survival, a widely accepted measure of healthspan. Methods: This prospective cohort study used data from the ASPirin in Reducing Events in the Elderly study. Participants were aged ≥70 years (or ≥65 years for African-American and Hispanic participants) and free of dementia, physical disability and cardiovascular disease. Depressive symptoms were measured using the 10-item Centre for Epidemiological Studies Depression Scale (CES-D-10). LLD and subthreshold depression were defined as CES-D-10 scores ≥8 and 3–7, respectively. Disability-free survival was defined as survival free of dementia and persistent physical disability. Results: A total of 19,110 participants were followed up for a maximum of 7.3 years. In female participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors, medical comorbidities, polypharmacy, physical function and antidepressant use (HR, 1.50; 95% CI, 1.23–1.82). In male participants, LLD was associated with lower disability-free survival adjusting for sociodemographic and lifestyle factors (HR, 1.30; 95% CI, 1.03–1.64). Subthreshold depression was also associated with lower disability-free survival in both sexes. Conclusions: LLD may be a common and important risk factor for shortened healthspan.
History
Journal
Acta Psychiatrica ScandinavicaVolume
147Pagination
92-104Location
United StatesPublisher DOI
ISSN
0001-690XeISSN
1600-0447Language
EnglishPublication classification
C1 Refereed article in a scholarly journalIssue
1Publisher
WILEYUsage metrics
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No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicinePsychiatryageingdisability-free survivalhealthspanlate-life depressionpsychiatryLATE-LIFE DEPRESSIONEXPECTANCYDISEASEBURDENRISKAgedHumansMaleFemaleDepressionProspective StudiesAntidepressive AgentsDisabled PersonsDementiaASPREE Investigator GroupPreventionBehavioral and Social ScienceMental HealthMajor Depressive DisorderClinical ResearchSerious Mental IllnessBrain DisordersAging2 Aetiology2.4 Surveillance and distribution3 Good Health and Well BeingMedical and Health SciencesPsychology and Cognitive Sciences
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