File(s) under permanent embargo
The effect of fenugreek seed supplementation on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus: a parallel randomized clinical trial
journal contribution
posted on 2020-03-01, 00:00 authored by A Hadi, A Arab, H Hajianfar, B Talaei, M Miraghajani, S Babajafari, Wolf MarxWolf Marx, R TavakolyObjectives: This study was designed to determine the effects of fenugreek seed (FS) on serum irisin levels, blood pressure, and liver and kidney function in patients with type 2 diabetes mellitus (T2DM). Methods: In an 8-week randomized controlled clinical trial, T2DM patients (n = 50) were assigned to the intervention (5 g FS powder, 3 times a day) or control group. Both groups received anti-diabetic drugs and nutritional consults. Serum samples were collected and blood pressure was measured at baseline and end of the trial. Data on dietary intake and physical activity was determined using the questionnaires. Results: Compared to the control group, FS consumption resulted in a significant decrease in fasting plasma glucose (FPG) (p = 0.024), as well as a significant change in serum alanine aminotransferase (ALT) (p = 0.02) and alkaline phosphatase (ALP) (p = 0.001). Within-group analysis showed a significant decrease in aspartate aminotransferase (AST) (p = 0.014), systolic blood pressure (SBP) (p = 0.001), and irisin (p = 0.001) in the FS group, and a significant increase in creatinine (Cr) (p = 0.001) and decrease in estimated glomerular filtration rate (eGFR) (p = 0.001) in the control group. FS consumption did not have any significant effect on diastolic blood pressure (DBP) and blood urea nitrogen (BUN). Conclusion: FS intake has some beneficial effects on FPG, SBP, and some liver and kidney function tests in patients with T2DM. Further studies are required to investigate the effect of FS on irisin levels. Trial registration number http://www.irct.ir, code: IRCT20190618043924N1
History
Journal
Complementary therapies in medicineVolume
49Article number
102315Pagination
1 - 5Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
0965-2299eISSN
1873-6963Language
engPublication classification
C1 Refereed article in a scholarly journalUsage metrics
Categories
No categories selectedKeywords
Science & TechnologyLife Sciences & BiomedicineIntegrative & Complementary MedicineDiabetesHypertensionIrisinKidneyLiverTrigonella foenum-graecumPhytotherapyInterventionNONALCOHOLIC FATTY LIVERCIRCULATING IRISININSULIN-RESISTANCEASSOCIATIONDIOSGENINGLUCOSE4-HYDROXYISOLEUCINEHYPERLIPIDEMIAPATHOGENESISPREVALENCE
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC