marx-effectofginger-2018.pdf (669.07 kB)
The effect of ginger (Zingiber officinale) on platelet aggregation: a systematic literature review
journal contribution
posted on 2015-10-21, 00:00 authored by Wolf MarxWolf Marx, Daniel McKavanagh, Alexandra L McCarthy, Robert Bird, Karin Ried, Alexandre Chan, Liz IsenringBACKGROUND: The potential effect of ginger on platelet aggregation is a widely-cited concern both within the published literature and to clinicians; however, there has been no systematic appraisal of the evidence to date. METHODS: Using the PRISMA guidelines, we systematically reviewed the results of clinical and observational trials regarding the effect of ginger on platelet aggregation in adults compared to either placebo or baseline data. Studies included in this review stipulated the independent variable was a ginger preparation or isolated ginger compound, and used measures of platelet aggregation as the primary outcome.
RESULTS: Ten studies were included, comprising eight clinical trials and two observational studies. Of the eight clinical trials, four reported that ginger reduced platelet aggregation, while the remaining four reported no effect. The two observational studies also reported mixed findings. DISCUSSION: Many of the studies appraised for this review had moderate risks of bias. Methodology varied considerably between studies, notably the timeframe studied, dose of ginger used, and the characteristics of subjects recruited (e.g. healthy vs. patients with chronic diseases).
CONCLUSION: The evidence that ginger affects platelet aggregation and coagulation is equivocal and further study is needed to definitively address this question.
RESULTS: Ten studies were included, comprising eight clinical trials and two observational studies. Of the eight clinical trials, four reported that ginger reduced platelet aggregation, while the remaining four reported no effect. The two observational studies also reported mixed findings. DISCUSSION: Many of the studies appraised for this review had moderate risks of bias. Methodology varied considerably between studies, notably the timeframe studied, dose of ginger used, and the characteristics of subjects recruited (e.g. healthy vs. patients with chronic diseases).
CONCLUSION: The evidence that ginger affects platelet aggregation and coagulation is equivocal and further study is needed to definitively address this question.
History
Journal
PLoS OneVolume
10Issue
10Pagination
e0141119 - e0141119Publisher
Public Library of ScienceLocation
San Francisco, Calif.Publisher DOI
Link to full text
eISSN
1932-6203Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2015, The AuthorsUsage metrics
Categories
No categories selectedKeywords
AdolescentAdultClinical Trials as TopicFemaleGingerHumansMalePhytotherapyPlant ExtractsPlatelet AggregationPlatelet Function TestsYoung AdultScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsALTERNATIVE MEDICINEANTIPLATELET AGGREGATIONTHROMBOXANE PRODUCTIONCOMPLEMENTARYCONSTITUENTSNAUSEACONSUMPTIONNIFEDIPINECOMPONENTSWARFARIN
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC