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The effect of intrauterine growth restriction on postnatal lung function: the fetal origins of postnatal lung disease
journal contribution
posted on 2001-12-01, 00:00 authored by Julie OwensThere is mounting evidence, based on epidemiological studies, that intrauterine growth restriction (IUGR) may lead to reduced lung function and an increased incidence of lung disease in adult life. There is however little experimental evidence to support these studies. Hypothesis: That IUGR permanently alters the development of the lungs resulting in persistently abnormal lung function postnatally. Methods: Lambs from twin pregnancies, with birthweights falling in the growth restricted range were studied at one week, three months and six months of age. Normally grown lambs from single pregnancies served as controls. Lung function studies were performed with the animals sedated and with endotracheal tubes in situ. FRC was measured using the Nitrogen washout technique. The raised volume rapid thoracic compression technique was used to obtain forced expiratory volumes and flows. Results: FRC, forced expiratory volume in 0.5 seconds (FEV0 5) and FVC were all lower in the IUGR group at the one week and three month studies (p<0.05 FEV0 5 at 3months, p<0.001 for others). All of these differences could be accounted for by correcting for body weight at the time of study. Although body weight remained significantly lower in the IUGR group at six months (p0.001), there were no significant differences between the groups in FRC, FEV0.5or FVC. Conclusions: In this model of IUGR, transient reductions in lung function were detected, however lung function normalised by six months of age. These findings do not support the hypothesis that IUGR leads to persistently abnormal lung function postnatally.
History
Journal
RespirologyVolume
6Issue
SUPPL. 1Publisher
WileyLocation
Chichester, Eng.ISSN
1323-7799Language
engPublication classification
C1.1 Refereed article in a scholarly journalUsage metrics
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