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The effect of oral administration of iron saturated-bovine lactoferrin encapsulated chitosan-nanocarriers on osteoarthritis

Version 2 2024-06-04, 13:20
Version 1 2014-10-28, 10:37
journal contribution
posted on 2024-06-04, 13:20 authored by Rasika SamarasingheRasika Samarasinghe, R Kanwar, J Kanwar
In this study, the therapeutic potentials of 100% iron saturated-bovine lactoferrin encapsulated in alginate-chitosan polymeric nanocarriers (AEC-CP-Fe-bLf-NCs) were examined in in vitro inflammatory OA model and in collagen-induced arthritis (CIA) mice. Oral administration of nanocarriers in mice were non-toxic and significantly induced disease modifying activity by reducing joint inflammation and downregulating the expression of catabolic genes, IL-1β, NO, JNK and MAPK. In addition, up-regulation of type II collagen, aggrecan and inflammation depleted iron and calcium metabolisms via inhibition of miRNA of iron transporting receptors was shown in AEC-CP-Fe-bLf-NCs treated mice.

History

Journal

Biomaterials

Volume

35

Pagination

7522-7534

Location

Amsterdam, The Netherlands

ISSN

0142-9612

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2014, Elsevier

Issue

26

Publisher

Elsevier

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