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The effectiveness of mindfulness-based interventions in inflammatory bowel disease: A Systematic Review & Meta-Analysis
journal contribution
posted on 2023-04-04, 01:15 authored by C Naude, David SkvarcDavid Skvarc, S Knowles, L Russell, Subhadra EvansSubhadra Evans, Antonina Mikocka-WalusAntonina Mikocka-WalusBackground: Mental health has been identified as contributing to the pathogenesis of Inflammatory Bowel Disease (IBD). Resultingly, psychotherapeutic interventions, such as Mindfulness-Based Interventions (MBI), have been increasingly investigated for improving IBD outcomes. Objectives: To systematically review the current state of evidence of MBI's for individuals living with IBD. Methods: We performed a systematic review searching Medline, PsychINFO, CINAHL, Embase, Cochrane and Scopus, to identify controlled clinical trials, investigating MBI's for various IBD biopsychosocial outcomes. Data was pooled using the inverse-variance random effects model, with restricted maximum likelihood estimation, providing the standardized mean difference (SMD) between control and experimental groups, at both short and long-term follow up. Results: We identified 8 studies with 575 participants. Meta-analytic results found that MBI's were more efficacious than control groups in the short-term improvement of stress (SMD = −0.38, 95% CI [−0.65, −0.10], p = 0.007), mindfulness (SMD = 0.59, 95% CI [0.36, 0.83], p = 0.00001), C-Reactive Protein (CRP) (SMD = −0.25, 95% CI [−0.49, −0.01], p = 0.04) and health-related quality of life (HRQoL) (SMD = 0.45, 95% CI [0.24, 0.66], p = 0.0001) (including all emotional, bowel, social and systemic subscales). This was maintained in the long-term for stress (SMD = −0.44, 95% CI [−0.88, −0.01], p < 0.05) and mindfulness (SMD = 0.52, 95% CI [0.14, 0.90], p = 0.008), but not for HRQoL, with no long-term data available for CRP. Conclusions: Given that MBI's appear to be effective in improving several IBD outcomes, they may be a useful adjuvant therapy in wholistic IBD care, with further trials warranted.
History
Journal
Journal of Psychosomatic ResearchVolume
169Article number
111232Pagination
111232-111232Location
EnglandPublisher DOI
ISSN
0022-3999eISSN
1879-1360Language
enPublisher
Elsevier BVUsage metrics
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No categories selectedKeywords
Crohn's diseaseInflammatory bowel diseaseMBCTMBIMBSR mindfulnessUlcerative colitisMind and BodyClinical ResearchInflammatory Bowel DiseaseMental HealthClinical Trials and Supportive ActivitiesBehavioral and Social ScienceAutoimmune DiseaseDigestive Diseases3 Good Health and Well BeingMedical and Health SciencesPsychology and Cognitive Sciences
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