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The extracellular matrix in cancer progression: role of hyalectan proteoglycans and ADAMTS enzymes

Version 2 2024-06-04, 13:08
Version 1 2017-01-19, 10:39
journal contribution
posted on 2024-06-04, 13:08 authored by Marley BinderMarley Binder, S McCoombe, ED Williams, DR McCulloch, Alister WardAlister Ward
Remodelling of the extracellular matrix (ECM) has emerged as a key factor in cancer progression. Proteoglycans, including versican and other hyalectans, represent major structural elements of the ECM where they interact with other important molecules, including the glycosaminoglycan hyaluronan and the CD44 cell surface receptor. The hyalectan proteoglycans are regulated through cleavage by the proteolytic actions of A Disintegrin-like And Metalloproteinase domain with Thrombospondin-1 motif (ADAMTS) family members. Alteration in the balance between hyalectan proteoglycans and ADAMTS enzymes has been proposed to be a crucial factor in cancer progression either in a positive or negative manner depending on the context. Further complexity arises due to the formation of bioactive cleavage products, such as versikine, which may also play a role, and non-enzymatic functions for ADAMTS proteins. This research is providing fresh insights into cancer biology and opportunities for the development of new diagnostic and treatment strategies.

History

Journal

Cancer letters

Volume

385

Pagination

55-64

Location

Amsterdam, The Netherlands

ISSN

0304-3835

eISSN

1872-7980

Language

eng

Publication classification

C Journal article, C1 Refereed article in a scholarly journal

Copyright notice

2016, Elsevier Ireland Ltd

Publisher

Elsevier