File(s) under permanent embargo
The gut microbiota and inflammatory noncommunicable diseases: associations and potentials for gut microbiota therapies
journal contribution
posted on 2015-01-31, 00:00 authored by C West, H Renz, M Jenmalm, A Kozyrski, K Allen, Peter VuillerminPeter Vuillermin, S PrescottRapid environmental transition and modern lifestyles are likely
driving changes in the biodiversity of the human gut microbiota.
With clear effects on physiologic, immunologic, and metabolic
processes in human health, aberrations in the gut microbiome
and intestinal homeostasis have the capacity for multisystem
effects. Changes in microbial composition are implicated in the
increasing propensity for a broad range of inflammatory
diseases, such as allergic disease, asthma, inflammatory bowel
disease (IBD), obesity, and associated noncommunicable
diseases (NCDs). There are also suggestive implications for
neurodevelopment and mental health. These diverse
multisystem influences have sparked interest in strategies that
might favorably modulate the gut microbiota to reduce the risk
of many NCDs. For example, specific prebiotics promote
favorable intestinal colonization, and their fermented products
have anti-inflammatory properties. Specific probiotics also have
immunomodulatory and metabolic effects. However, when
evaluated in clinical trials, the effects are variable, preliminary,
or limited in magnitude. Fecal microbiota transplantation is
another emerging therapy that regulates inflammation in
experimental models. In human subjects it has been successfully
used in cases of Clostridium difficile infection and IBD, although
controlled trials are lacking for IBD. Here we discuss
relationships between gut colonization and inflammatory NCDs
and gut microbiota modulation strategies for their treatment
and prevention. (J Allergy Clin Immunol 2015;135:3-13.)
driving changes in the biodiversity of the human gut microbiota.
With clear effects on physiologic, immunologic, and metabolic
processes in human health, aberrations in the gut microbiome
and intestinal homeostasis have the capacity for multisystem
effects. Changes in microbial composition are implicated in the
increasing propensity for a broad range of inflammatory
diseases, such as allergic disease, asthma, inflammatory bowel
disease (IBD), obesity, and associated noncommunicable
diseases (NCDs). There are also suggestive implications for
neurodevelopment and mental health. These diverse
multisystem influences have sparked interest in strategies that
might favorably modulate the gut microbiota to reduce the risk
of many NCDs. For example, specific prebiotics promote
favorable intestinal colonization, and their fermented products
have anti-inflammatory properties. Specific probiotics also have
immunomodulatory and metabolic effects. However, when
evaluated in clinical trials, the effects are variable, preliminary,
or limited in magnitude. Fecal microbiota transplantation is
another emerging therapy that regulates inflammation in
experimental models. In human subjects it has been successfully
used in cases of Clostridium difficile infection and IBD, although
controlled trials are lacking for IBD. Here we discuss
relationships between gut colonization and inflammatory NCDs
and gut microbiota modulation strategies for their treatment
and prevention. (J Allergy Clin Immunol 2015;135:3-13.)
History
Journal
Journal of allergy and clinical immunologyVolume
135Issue
1Pagination
3 - 13Publisher
ElsevierLocation
Amsterdam, The NetherlandsPublisher DOI
ISSN
1097-6825Language
eng.Publication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2014 American Academy of Allergy, Asthma & ImmunologyEditor/Contributor(s)
D Leong, D LedfordUsage metrics
Categories
Keywords
fecal microbiota transplantationgut microbiomeiflammationnoncommunicable diseasesprebioticsprobioticsshort-chain fatty acidsScience & TechnologyLife Sciences & BiomedicineAllergyImmunologyinflammationCLOSTRIDIUM-DIFFICILE INFECTIONFECAL MICROBIOTAINTESTINAL MICROBIOTAALLERGIC DISEASEEARLY-LIFEPROBIOTIC SUPPLEMENTATIONHEALTHY-CHILDRENCESAREAN-SECTIONFOLLOW-UPAT-RISKin-FLAME Microbiome Interest GroupImmunology
Licence
Exports
RefWorks
BibTeX
Ref. manager
Endnote
DataCite
NLM
DC