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The initiating dialysis early and late (ideal) study: Study rationale and design

Version 2 2024-06-04, 13:31
Version 1 2018-07-27, 12:16
journal contribution
posted on 2024-06-04, 13:31 authored by BA Cooper, P Branley, L Bulfone, JF Collins, JC Craig, J Dempster, MB Fraenkel, A Harris, DC Harris, DW Johnson, J Kesselhut, G Luxton, A Pilmore, CA Pollock, DJ Tiller
◆ Objectives: The primary objective of the IDEAL study is to determine whether the timing of dialysis initiation has an effect on survival in subjects with end-stage renal disease (ESRD). The secondary objectives are to determine the impact of "early start" versus "late start" dialysis on nutritional and cardiac morbidity, quality of life, and economic cost. ◆ Design: Prospective multicenter randomized controlled trial. Patients are randomized to commence dialysis at a glomerular filtration rate (by Cockcroft-Gault) of either 10 - 14 mL/minute/1.73 m2 ("early start") or 5 - 7 mL/min/1.73 m2 ("late start"), with stratification for dialysis modality (hemodialysis vs peritoneal dialysis), study center, and the presence or not of diabetes mellitus. ◆ Setting: Dialysis units throughout Australia and New Zealand. ◆ Patients: Patients with ESRD commencing chronic dialysis therapy. ◆ Outcome Measures: Three years from randomization, all-cause mortality, morbidity, and economic impact; structural and functional cardiac status, nutritional state, and quality of life will be assessed. ◆ Results: To date, 388 patients of a minimum 800 patients have been entered and randomized into the study. Current recruitment rates suggest sufficient patients will be enrolled by December 2004 and follow-up completed by December 2007. ◆ Conclusions: The IDEAL study will provide evidence for the optimal time to commence dialysis. Copyright © 2004 International Society for Peritoneal Dialysis.

History

Journal

Peritoneal dialysis international : journal of the International Society for Peritoneal Dialysis

Volume

24

Pagination

176-181

Location

Downsview Ont.

ISSN

0896-8608

Publication classification

C1.1 Refereed article in a scholarly journal

Issue

2

Publisher

Multimed

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