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The new ‘5-HT’ hypothesis of depression : cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
journal contribution
posted on 2011-04-29, 00:00 authored by M. Maes, B Leonard, A Myint, M Kubera, R VerkerkThe new ‘5-HT’ hypothesis of depression : cell-mediated immune activation induces indoleamine 2,3-dioxygenase, which leads to lower plasma tryptophan and an increased synthesis of detrimental tryptophan catabolites (TRYCATs), both of which contribute to the onset of depression
History
Journal
Progress in neuro-psychopharmacology and biological psychiatryVolume
35Issue
3Pagination
702 - 721Publisher
ElsevierLocation
Philadelphia, Pa.Publisher DOI
ISSN
0278-5846eISSN
1878-4216Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2010, Elsevier Inc.Usage metrics
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No categories selectedKeywords
depressiontryptophanindoleamine 23-dioxygenasecytokinescell-mediated immune activationinflammationScience & TechnologyLife Sciences & BiomedicineClinical NeurologyNeurosciencesPharmacology & PharmacyPsychiatryNeurosciences & NeurologyIndoleamine 2,3-dioxygenaseNECROSIS-FACTOR-ALPHADEXAMETHASONE-SUPPRESSION TESTKYNURENINE PATHWAY METABOLISMOLFACTORY BULBECTOMIZED RATDECREASED SERUM TRYPTOPHANGROWTH-FACTOR-BETAMETHYL-D-ASPARTATEAMINO-ACID RATIOQUINOLINIC ACIDINTERFERON-ALPHA
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