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The platelet intracellular calcium response to serotonin and thrombin in patients with panic disorder.

journal contribution
posted on 1999-01-01, 00:00 authored by H Plein, Michael BerkMichael Berk
Serotonin is implicated in both the biology of depression and anxiety. The aim of this study was to examine the platelet intracellular calcium response to serotonin and thrombin using spectrofluorometry in 14 patients with DSM-4 panic disorder compared to 14 matched controls. Patients did not show significantly higher baseline platelet intracellular calcium levels and serotonin stimulated levels of intracellular calcium than control subjects. There was a much smaller standard deviation in the control subjects than in the panic patients. The intracellular calcium response to thrombin activation was however greater in panic patients than in control subjects (P<0.001). The failure of this study to find enhanced sensitivity of 5-HT2 receptors in panic disorder is compatible with the findings of previous challenge studies that found no consistent dysregulation of serotonin in panic disorder. The enhanced thrombin sensitivity, nevertheless suggests some receptor mediated second messenger changes independent of serotonin in the disorder.

History

Journal

European Neuropsychopharmacology

Volume

9

Issue

1-2

Pagination

107 - 110

Publisher

Elsevier

Location

NETHERLANDS

ISSN

1873-7862

Language

eng

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

1999, Elsevier