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The platelet window: examining receptor regulated second messenger processes in psychosis and depression

Version 2 2024-06-02, 13:17
Version 1 2015-03-18, 10:46
journal contribution
posted on 2024-06-02, 13:17 authored by Michael BerkMichael Berk, GS Mahlhi
Peripheral markers of psychiatric illness provide a potentially important window into the pathophysiology of a number of psychiatric illnesses. Direct access to pathophysiological processes is fraught with difficulty. However, receptor-regulated second messenger-mediated calcium shifts are an accessible and practical method by which to examine changes in a clinical population. This is possible because platelets and neurons share some physiological features. The platelet intracellular calcium response to receptor stimulation has previously been used as a peripheral marker of psychiatric illness across a range of neurotransmitters, including serotonin, dopamine and glutamate. This review considers the specificity and selectivity of this response and its use in psychotic and mood disorders.

History

Journal

Acta Neuropsychiatrica

Volume

15

Pagination

309-315

Location

England

ISSN

0924-2708

eISSN

1601-5215

Language

English

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2003, Wiley

Issue

6

Publisher

Wiley