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Download fileThe potential of carnosine in brain-related disorders: a comprehensive review of current evidence
journal contribution
posted on 2019-06-01, 00:00 authored by M Schön, A Mousa, Michael BerkMichael Berk, W L Chia, J Ukropec, A Majid, B Ukropcová, B De CourtenNeurological, neurodegenerative, and psychiatric disorders represent a serious burden because of their increasing prevalence, risk of disability, and the lack of effective causal/disease-modifying treatments. There is a growing body of evidence indicating potentially favourable effects of carnosine, which is an over-the-counter food supplement, in peripheral tissues. Although most studies to date have focused on the role of carnosine in metabolic and cardiovascular disorders, the physiological presence of this di-peptide and its analogues in the brain together with their ability to cross the blood-brain barrier as well as evidence from in vitro, animal, and human studies suggest carnosine as a promising therapeutic target in brain disorders. In this review, we aim to provide a comprehensive overview of the role of carnosine in neurological, neurodevelopmental, neurodegenerative, and psychiatric disorders, summarizing current evidence from cell, animal, and human cross-sectional, longitudinal studies, and randomized controlled trials.
History
Journal
NutrientsVolume
11Issue
6Pagination
1 - 26Publisher
MDPILocation
Basel, SwitzerlandPublisher DOI
Link to full text
eISSN
2072-6643Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2019, the authorsUsage metrics
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Categories
Keywords
carnosineL-histidineβ-alaninebraincognitiontreatmentpsychiatryneurologynervous systemScience & TechnologyLife Sciences & BiomedicineNutrition & Dieteticsbeta-alanineMAJOR DEPRESSIVE DISORDERSHORT-TERM-MEMORYAMINO-ACIDDOUBLE-BLINDALZHEIMERS-DISEASEPARKINSONS-DISEASECEREBRAL-ISCHEMIACOGNITIVE DEFICITS-alanine