austin-promiseperilchemical-2015.pdf (392.44 kB)
The promise and peril of chemical probes
journal contribution
posted on 2015-08-01, 00:00 authored by C H Arrowsmith, J E Audia, Chris AustinChris Austin, J Baell, J Bennett, J Blagg, C Bountra, P E Brennan, P J Brown, M E Bunnage, C Buser-Doepner, R M Campbell, A J Carter, P Cohen, R A Copeland, B Cravatt, J L Dahlin, D Dhanak, A M Edwards, M FrederiksenChemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of
poor quality or that are used incorrectly generate misleading results. To help address these shortcomings,
we will create a community-driven wiki resource to improve quality and convey current best practice
poor quality or that are used incorrectly generate misleading results. To help address these shortcomings,
we will create a community-driven wiki resource to improve quality and convey current best practice
History
Journal
Nature chemical biologyVolume
11Issue
8Pagination
536 - 541Publisher
Nature Publishing GroupLocation
London, Eng.Publisher DOI
Link to full text
ISSN
1552-4450eISSN
1552-4469Language
engPublication classification
C Journal article; C1.1 Refereed article in a scholarly journalCopyright notice
2016, Nature AmericaUsage metrics
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No categories selectedKeywords
Biomedical ResearchHumansInformation DisseminationIntellectual PropertyInternetMolecular ProbesMolecular WeightSensitivity and SpecificitySmall Molecule LibrariesScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyPROTEIN-KINASETARGET ENGAGEMENTPOTENT INHIBITORIDENTIFICATIONHYDROLASEMECHANISMAGONISTCELLS
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