The promise and peril of chemical probes
Version 2 2024-05-30, 09:56
Version 1 2017-02-15, 13:57
journal contribution
posted on 2024-05-30, 09:56 authored by CH Arrowsmith, JE Audia, Chris AustinChris Austin, J Baell, J Bennett, J Blagg, C Bountra, PE Brennan, PJ Brown, ME Bunnage, C Buser-Doepner, RM Campbell, AJ Carter, P Cohen, RA Copeland, B Cravatt, JL Dahlin, D Dhanak, AM Edwards, M FrederiksenChemical probes are powerful reagents with increasing impacts on biomedical research. However, probes of
poor quality or that are used incorrectly generate misleading results. To help address these shortcomings,
we will create a community-driven wiki resource to improve quality and convey current best practice
History
Journal
Nature chemical biologyVolume
11Pagination
536-541Location
London, Eng.Publisher DOI
Open access
- Yes
Link to full text
ISSN
1552-4450eISSN
1552-4469Language
engPublication classification
C Journal article, C1.1 Refereed article in a scholarly journalCopyright notice
2016, Nature AmericaIssue
8Publisher
Nature Publishing GroupPublication URL
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Keywords
Biomedical ResearchHumansInformation DisseminationIntellectual PropertyInternetMolecular ProbesMolecular WeightSensitivity and SpecificitySmall Molecule LibrariesScience & TechnologyLife Sciences & BiomedicineBiochemistry & Molecular BiologyPROTEIN-KINASETARGET ENGAGEMENTPOTENT INHIBITORIDENTIFICATIONHYDROLASEMECHANISMAGONISTCELLS030499 Medicinal and Biomolecular Chemistry not elsewhere classified970106 Expanding Knowledge in the Biological SciencesSchool of Life and Environmental Sciences
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