alexandersen-protectivcapacity-2018.pdf (2 MB)
The protective capacity of high payload FMDV A22 IRQ vaccine in sheep against direct-contact challenge with a heterologous, contemporary FMDV A strain from South East Asia
journal contribution
posted on 2018-06-18, 00:00 authored by Jacquelyn Horsington, Charles Nfon, Hilary Bittner, Peter A Durr, Nagendrakumar Singanallur, Soren AlexandersenSoren Alexandersen, Wilna VoslooFoot-and-mouth disease (FMD) is an acute, highly contagious viral disease of domestic and wild cloven-hoofed animals, caused by FMD virus (FMDV). An FMD outbreak can cause major production losses and have significant implications for trade. Vaccination can assist in controlling the disease, and emergency vaccination using high antigen payload vaccines (>6 PD50/dose) is considered an important control approach in the event of an outbreak. In recent years there has been a divergence of serotype A viruses in South East Asia (SEA) into several distinct genetic and antigenic clusters. Numerous variants were found to poorly match serotype A vaccines commonly included in international antigen banks. This study examined the ability of single vaccination with high-potency monovalent A22 IRQ vaccine to protect sheep following challenge with the A/VIT/15/2012 strain, just four days following vaccination. The vaccine proved effective at limiting clinical disease but did not prevent infection.
History
Journal
PLoS oneVolume
13Issue
6Article number
e0195302Pagination
1 - 15Publisher
Public Library of ScienceLocation
San Francisco, Calif.Publisher DOI
Link to full text
eISSN
1932-6203Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2018, Horsington et al.Usage metrics
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No categories selectedKeywords
sheepfoot and mouth diseaselivestockvaccinesantibodiesveterinary diseasesenzyme-linked immunoassaysvaccinationimmunisationScience & TechnologyMultidisciplinary SciencesScience & Technology - Other TopicsMOUTH-DISEASE VIRUSEMERGENCY VACCINATIONSUBCLINICAL INFECTIONCARRIER STATEHIGH-POTENCYCLINICAL-PROTECTIONCATTLEPIGSTRANSMISSIONPERSISTENCE
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