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The regulation and function of the striated muscle activator of rho signaling (STARS) protein

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journal contribution
posted on 01.12.2012, 00:00 authored by Marita Wallace, Severine LamonSeverine Lamon, Aaron RussellAaron Russell
Healthy living throughout the lifespan requires continual growth and repair of cardiac, smooth, and skeletal muscle. To effectively maintain these processes muscle cells detect extracellular stress signals and efficiently transmit them to activate appropriate intracellular transcriptional programs. The striated muscle activator of Rho signaling (STARS) protein, also known as Myocyte Stress-1 (MS1) protein and Actin-binding Rho-activating protein (ABRA) is highly enriched in cardiac, skeletal, and smooth muscle. STARS binds actin, co-localizes to the sarcomere and is able to stabilize the actin cytoskeleton. By regulating actin polymerization, STARS also controls an intracellular signaling cascade that stimulates the serum response factor (SRF) transcriptional pathway; a pathway controlling genes involved in muscle cell proliferation, differentiation, and growth. Understanding the activation, transcriptional control and biological roles of STARS in cardiac, smooth, and skeletal muscle, will improve our understanding of physiological and pathophysiological muscle development and function.

History

Journal

Frontiers in physiology

Volume

3

Issue

Article 469

Pagination

1 - 5

Publisher

Frontiers Research Foundation

Location

Lausanne, Switzerland

ISSN

1664-042X

eISSN

1664-1078

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2012, Frontiers Research Foundation