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The regulation of glucose metabolism: implications and considerations for the assessment of glucose homeostasis in rodents
journal contribution
posted on 2014-11-01, 00:00 authored by Greg KowalskiGreg Kowalski, Clinton BruceClinton BruceThe incidence of insulin resistance and type 2 diabetes (T2D) is increasing at alarming rates. In the quest to understand the underlying causes of and to identify novel therapeutic targets to treat T2D, scientists have become increasingly reliant on the use of rodent models. Here, we provide a discussion on the regulation of rodent glucose metabolism, highlighting key differences and similarities that exist between rodents and humans. In addition, some of the issues and considerations associated with assessing glucose homeostasis and insulin action are outlined. We also discuss the role of the liver vs. skeletal muscle in regulating whole body glucose metabolism in rodents, emphasizing the importance of defective hepatic glucose metabolism in the development of impaired glucose tolerance, insulin resistance, and T2D. © 2014 the American Physiological Society.
History
Journal
American journal of physiology-endocrinology and metabolismVolume
307Issue
10Article number
10Pagination
E859 - E871Publisher
American Physiological SocietyLocation
Bethesda, MDPublisher DOI
ISSN
0193-1849eISSN
1522-1555Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2014, American Physiological SocietyUsage metrics
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No categories selectedKeywords
Endogenous glucose productionGluconeogenesisGlucose toleranceInsulin resistanceType 2 diabetesScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismPhysiologyDEPENDENT DIABETES-MELLITUSFREE FATTY-ACIDBROWN ADIPOSE-TISSUEDUCHENNE-MUSCULAR-DYSTROPHYHEPATIC INSULIN-RESISTANCERECEPTOR KNOCKOUT MICEBETA-CELL DYSFUNCTIONDOSE-RESPONSE CURVESMIXED MEALIN-VIVO
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