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The role and regulation of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy

journal contribution
posted on 01.03.2011, 00:00 authored by Victoria Foletta, L White, Amy Larsen, B Léger, Aaron RussellAaron Russell
Skeletal muscle atrophy occurs in many chronic diseases and disuse conditions. Its severity reduces patient recovery, independence and quality of life. The discovery of two muscle-specific E3 ubiquitin ligases, MAFbx/ atrogin-1 and Muscle RING Finger-1 (MuRF1), promoted an expectation of these molecules as targets for therapeutic development. While numerous studies have determined the conditions in which MAFbx/atrogin-1 and MuRF1 mRNA levels are regulated, few studies have investigated their functional role in skeletal muscle. Recently, studies identifying new target substrates for MAFbx/atrogin-1 and
MuRF1, outside of their response to the initiation of muscle atrophy, suggest that there is more to these proteins than
previously appreciated. This review will highlight our present knowledge of MAFbx/atrogin-1 and MuRF1 in skeletal muscle atrophy, the impact of potential therapeutics and their known regulators and substrates. Finally, we will comment on new approaches that may expand our knowledge of these two molecules in their control of skeletal muscle function.

History

Journal

Pfluegers Archiv: European journal of physiology

Volume

461

Issue

3

Pagination

325 - 335

Publisher

Springer

Location

Heidelberg, Germany

ISSN

0031-6768

eISSN

1432-2013

Language

eng

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2011, Springer-Verlag