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The role of depression pharmacogenetic decision support tools in shared decision making

journal contribution
posted on 2019-01-01, 00:00 authored by K Arandjelovic, H A Eyre, E Lenze, Ajeet SinghAjeet Singh, Michael BerkMichael Berk, C Bousman
Patients discontinue antidepressant medications due to lack of knowledge, unrealistic expectations, and/or unacceptable side effects. Shared decision making (SDM) invites patients to play an active role in their treatment and may indirectly improve outcomes through enhanced engagement in care, adherence to treatment, and positive expectancy of medication outcomes. We believe decisional aids, such as pharmacogenetic decision support tools (PDSTs), facilitate SDM in the clinical setting. PDSTs may likewise predict drug tolerance and efficacy, and therefore adherence and effectiveness on an individual-patient level. There are several important ethical considerations to be navigated when integrating PDSTs into clinical practice. The field requires greater empirical research to demonstrate clinical utility, and the mechanisms thereof, as well as exploration of the ethical use of these technologies.

History

Journal

Journal of neural transmission

Volume

126

Issue

1

Pagination

87 - 94

Publisher

Springer

Location

Vienna, Austria

eISSN

1435-1463

Language

eng

Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2017, Springer-Verlag GmbH Austria