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The role of hypernitrosylation in the pathogenesis and pathophysiology of neuroprogressive diseases

journal contribution
posted on 2018-01-01, 00:00 authored by G Morris, Ken WalderKen Walder, A F Carvalho, Susannah Tye, K Lucas, Michael BerkMichael Berk, M Maes
There is a wealth of data indicating that de novo protein S-nitrosylation in general and protein transnitrosylation in particular mediates the bulk of nitric oxide signalling. These processes enable redox sensing and facilitate homeostatic regulation of redox dependent protein signalling, function, stability and trafficking. Increased S-nitrosylation in an environment of increasing oxidative and nitrosative stress (O&NS) is initially a protective mechanism aimed at maintaining protein structure and function. When O&NS becomes severe, mechanisms governing denitrosylation and transnitrosylation break down leading to the pathological state referred to as hypernitrosylation (HN). Such a state has been implicated in the pathogenesis and pathophysiology of several neuropsychiatric and neurodegenerative diseases and we investigate its potential role in the development and maintenance of neuroprogressive disorders. In this paper, we propose a model whereby the hypernitrosylation of a range of functional proteins and enzymes lead to changes in activity which conspire to produce at least some of the core abnormalities contributing to the development and maintenance of pathology in these illnesses.



Neuroscience and biobehavioral reviews




453 - 469




Amsterdam, The Netherlands





Publication classification

C Journal article; C1 Refereed article in a scholarly journal

Copyright notice

2018, Elsevier