Deakin University
Browse
bortolasci-therapeuticpotential-2019.pdf (1.39 MB)

The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

Download (1.39 MB)
Version 4 2024-06-18, 14:05
Version 3 2024-06-13, 15:38
Version 2 2024-06-04, 14:09
Version 1 2019-03-29, 08:46
journal contribution
posted on 2024-06-18, 14:05 authored by Melanie AshtonMelanie Ashton, Olivia DeanOlivia Dean, Adam WalkerAdam Walker, CC Bortolasci, CH Ng, M Hopwood, BH Harvey, M Möller, JJ McGrath, Wolf MarxWolf Marx, Alyna TurnerAlyna Turner, Seetal DoddSeetal Dodd, JG Scott, JP Khoo, Ken WalderKen Walder, J Sarris, Michael BerkMichael Berk
New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.

History

Journal

Frontiers in Psychiatry

Volume

10

Article number

ARTN 115

Pagination

1 - 17

Location

Switzerland

Open access

  • Yes

ISSN

1664-0640

eISSN

1664-0640

Language

English

Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Ashton, Dean, Walker, Bortolasci, Ng, Hopwood, Harvey, Möller, McGrath, Marx, Turner, Dodd, Scott, Khoo, Walder, Sarris and Berk

Issue

MAR

Publisher

FRONTIERS MEDIA SA