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The therapeutic potential of mangosteen pericarp as an adjunctive therapy for bipolar disorder and schizophrenia

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journal contribution
posted on 2019-03-01, 00:00 authored by Melanie AshtonMelanie Ashton, Olivia DeanOlivia Dean, Adam WalkerAdam Walker, Chiara BortolasciChiara Bortolasci, Chee H Ng, Malcolm Hopwood, Brian H Harvey, Marisa Möller, John J McGrath, Wolf MarxWolf Marx, Alyna TurnerAlyna Turner, Seetal DoddSeetal Dodd, James G Scott, Jon-Paul Khoo, Ken WalderKen Walder, Jerome Sarris, Michael BerkMichael Berk
New treatments are urgently needed for serious mental illnesses including bipolar disorder and schizophrenia. This review proposes that Garcinia mangostana Linn. (mangosteen) pericarp is a possible adjunctive therapeutic agent for these disorders. Research to date demonstrates that neurobiological properties of the mangosteen pericarp are well aligned with the current understanding of the pathophysiology of bipolar disorder and schizophrenia. Mangosteen pericarp has antioxidant, putative neuroprotective, anti-inflammatory, and putative mitochondrial enhancing properties, with animal studies demonstrating favorable pharmacotherapeutic benefits with respect to these disorders. This review summarizes evidence of its properties and supports the case for future studies to assess the utility of mangosteen pericarp as an adjunctive treatment option for mood and psychotic disorders.



Frontiers in psychiatry



Article number



1 - 17


Frontiers Media


Lausanne, Switzerland





Publication classification

C1 Refereed article in a scholarly journal

Copyright notice

2019, Ashton, Dean, Walker, Bortolasci, Ng, Hopwood, Harvey, Möller, McGrath, Marx, Turner, Dodd, Scott, Khoo, Walder, Sarris and Berk