The use of microfluidic devices in studies of differential sperm chemotaxis

Differential sperm chemotaxis describes differences among male–female pairings in chemotactic responses of sperm to egg (or female)-derived chemical attractants. Microfluidic devices provide powerful platforms in which to study this complex gamete interaction. Here, we describe key challenges and potential solutions in applying this state-of-the-art technique to differential sperm chemotaxis.