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The utility of dried blood spots for proteomic studies: looking forward to looking back
journal contribution
posted on 2014-12-01, 00:00 authored by Vera Ignjatovic, James Pitt, Paul Monagle, Jeffrey CraigJeffrey CraigThe possibility to detect biomarkers of adult disease in early life and particularly in newborns holds enormous promise for early disease detection and prevention. Early detection of disease or potential for future disease would allow for prevention or amelioration of disease before overt symptoms develop, by lifestyle modifications, appropriate medication and monitoring. It is now increasingly important to develop the technologies that allow dried blood spots (DBS) to be utilized for protein-based studies. The use of DBS in proteome wide association studies (PWAS) may in turn allow for detection of major diseases of adulthood at the earliest possible time. This review focuses on the utility of DBS in proteomics, the main challenges, as well as the latest approaches for overcoming those, facilitating the use of DBS for detection of major diseases of adulthood at the earliest possible time.
History
Journal
Proteomics clinical applicationsVolume
8Issue
11-12Pagination
896 - 900Publisher
WileyLocation
London, Eng.Publisher DOI
eISSN
1862-8354Language
engPublication classification
C1 Refereed article in a scholarly journalCopyright notice
2014, WileyUsage metrics
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No categories selectedKeywords
Disease preventionDried blood spotsAdultBiomarkersBlood ProteinsBlood Specimen CollectionDried Blood Spot TestingHumansInfant, NewbornProteomeProteomicsReproducibility of ResultsScience & TechnologyLife Sciences & BiomedicineBiochemical Research MethodsBiochemistry & Molecular BiologyDNA METHYLATIONENDOGENOUS PROTEINSDISEASEBIRTHRETENTIONNUTRITIONLIFE
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