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The vasodilatory actions of insulin on resistance and terminal arterioles and their impact on muscle glucose uptake
journal contribution
posted on 2004-01-01, 00:00 authored by L H Clerk, Michelle KeskeMichelle Keske, J R Lindner, M G Clark, S Rattigan, E J BarrettWhether a discrete vascular action of insulin in skeletal muscle integrally participates in insulin-mediated glucose disposal has been extensively examined but remains a contentious issue. Here, we review some of the data both supporting and questioning the role of insulin-mediated increases in limb blood flow in glucose metabolism. We advance the hypothesis that controversy has arisen, at least in part, from a failure to recognize that insulin exerts at least three separate actions on the peripheral vasculature, each with its own characteristic dose and time responsiveness. We summarize how, viewed in this manner, certain points of contention can be resolved. We also advance the hypothesis that an action on the precapillary arteriole may play the dominant role in mediating perfusion-dependent effects of insulin on glucose metabolism in muscle.
History
Journal
Diabetes/Metabolism research and reviewsVolume
20Issue
1Pagination
3 - 12Publisher
John Wiley & SonsLocation
Chichester, Eng.Publisher DOI
ISSN
1520-7552Language
engPublication classification
C1.1 Refereed article in a scholarly journalCopyright notice
2003, John Wiley & SonsUsage metrics
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AnimalsArteriolesBiological TransportEndothelium, VascularGlucoseHumansInsulinMicrocirculationMuscle, SkeletalVascular ResistanceVasodilationcontrast ultrasound1-methylxanthinecapillary recruitmentnitric oxide synthaseinsulin sensitivitymuscle blood flowScience & TechnologyLife Sciences & BiomedicineEndocrinology & MetabolismNITRIC-OXIDE SYNTHASEHUMAN SKELETAL-MUSCLEMEDIATED CAPILLARY RECRUITMENTBLOOD-FLOW HETEROGENEITYANGIOTENSIN-IISODIUM-NITROPRUSSIDEL-ARGININEIN-VIVOHEMODYNAMIC ACTIONSINCREASES
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