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The zebrafish as a model system for human disease

journal contribution
posted on 2002-04-01, 00:00 authored by Alister WardAlister Ward, G Lieschke
The zebrafish (Danio rerio) has been widely utilised for the study of developmental biology, which has lead to the evolution of sophisticated cellular and molecular approaches. More recently, the rapid progress of various zebrafish genomic infrastructure initiatives is facilitating the development of zebrafish models of human disease. This review aims to describe several representative examples of how the zebrafish can be successfully used to identify novel genes and assign gene function, providing invaluable clues to human pathophysiology.

History

Journal

Frontiers in bioscience

Volume

7

Location

Tampa, Fla.

ISSN

1093-9946

eISSN

1093-4715

Language

eng

Notes

Table of contents 1. Abstract 2. Introduction 3. Disease models 3.1. Hematopoietic models 3.2. Renal models 3.3. Cardiac models 3.4. Other developmental diseases 4. Perspective 5. Acknowledgements 6. References

Publication classification

C1.1 Refereed article in a scholarly journal

Copyright notice

2002, Frontiers in Bioscience

Issue

1-3

Publisher

Frontiers in Bioscience

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